The cause of diabetic neuropathy may vary, as there can be much combination of factors:
- Metabolic factors, such as the length of time you had diabetes, the level of blood glucose, the possibly of low levels of insulin, and abnormal blood fat levels.
- Neurovascular factors, which leads to damages to the blood vessels that carry oxygen and nutrients to the nerves.
- Autoimmune factors that may cause inflammation of the nerves.
- Mechanical injury to the nerves.
- Inherited traits that may increase the chances of getting nerve disease.
- Lifestyle factors, including smoking or alcohol use.
Diabetics are more likely to develop nerve damages because of the constant high blood glucose (sugar) levels. This tends to destroy both the nerve fiber (axon) and the fatty insulation that surrounds it (myelin).